First thing is first! I think a list of great stand-up comedians and a few links to some good stuff is in order.

If you haven't been exposed to Brian Reagan, Jim Gaffigan, Demitri Martin and the like, you owe it to yourself.




Here are some more good video clips from Brian Reagan:
Brian's Take on Doctors
String Theory

Then we have the infamous Jim Gaffigan:
Comedy Central Clips

All these clips from comedy central are classics.